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Summary

Gavi, the Vaccine Alliance, pools donor funds to increase immunization rates in developing countries. Vaccines have saved millions of lives.

[1]

Results from new research at the Center for Global Development suggest Gavi could save more lives by shifting support
away from lower-cost vaccines provided to middle-income countries toward more underused vaccines and support to the poorest countries.

Since 2000, Gavi has disbursed $5.3 billion worth of vaccines and $1.7 billion in financing to 77 countries with a combined population of 4.5 billion.

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In 2014, Gavi shipped 169 million doses of the pentavalent vaccine (a combined vaccine against diphtheria, pertussis, tetanus [DPT], Haemophilus influenza
type B [Hib], and hepatitis B [hep B]), enough to provide a full course of the vaccine to 79 percent of infants in participating countries.

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The Alliance has also funded performance-based payments for increased DPT immunization coverage ($20 per additional infant covered), though this program
was discontinued starting in 2013. The Alliance employs an income-based eligibility criterion for its support that initially excluded all countries with a
per capita gross national income (GNI) in excess of $1,000 in 1998 at market exchange rates and currently excludes countries above $1,570. Countries with
per capita income that crosses this threshold are no longer eligible to apply for new vaccine support, but can continue receiving support for existing
vaccines for five years. During this period, countries pay an increasing share until 100 percent of vaccine costs are covered by domestic sources.

Gavi recently completed a $7.5 billion replenishment process to raise funds for the period 2016 to 2020. As part of the replenishment, Gavi is considering
changes to its model, including modifying the types and targets of support. This brief builds on research presented in a companion paper (“Are Vaccines
Fungible? Regression Discontinuity Evidence from a Large Aid Program”) to provide policy suggestions to help inform these discussions.

Progress on Vaccination since 2000

Vaccination coverage in poor countries has increased over the last ten years, ending the stagnation from the decade before. The DPT coverage rate in
low-income countries averaged 59 percent in both 1990 and 2000, but by 2012 it had climbed to 81 percent. Over the same period, several newer immunizations
became rapidly available and widely used. Figure 1 compares vaccine coverage rates in Gavi-eligible countries to a sample of higher-income Gavi-ineligible
developing countries in 2000 and 2013

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. Hep B coverage rates in particular increased dramatically in eligible countries over that period, considerably shrinking the gap in coverage between
eligible and ineligible countries. Two immunizations that were not in the standard schedule in 2000 (rotavirus and pneumococcal) had begun to roll out by
2008.

Figure 1: Vaccination Trends by Gavi Eligibility

Vaccination trends by Gavi eligibility

Gavi’s Impact on Immunization Rates

The Alliance’s large purchases combined with a specific strategy to bring new vaccines into the market grew the market for vaccines and may have
contributed to a drop in vaccine prices over time. Between 2000 and 2012 the price UNICEF paid for the hep B vaccine dropped from US$ 0.55 to US$ 0.19 per
dose, for example. For Gavi-ineligible countries, UNICEF purchased DPT doses for $0.17 on average in 2012, pentavalent for $2.16, rotavirus for $5, and
pneumococcal doses for $7.

The very rapid adoption of hep B and Hib is consistent with a story that Gavi facilitated rollout of coverage through the provision of the pentavalent
combination vaccine especially in the poorest countries.

Alongside purchasing a significant quantity of vaccines, Gavi supported the development of the pneumococcal vaccine containing serotypes prevalent in
low-income countries through an advance market commitment (AMC). It’s not clear the tailored vaccine would have existed by 2010 without the Alliance’s
efforts. The cost of the vaccine was capped at $7 for the first 20 percent of the supply to developing countries and $3.50 for the remainder as part of the
AMC agreement.

At the same time, there is evidence that Gavi support for low-cost vaccines included as part of the pentavalent package may have displaced doses that
countries would have purchased absent Gavi. Figure 2 displays 2013 GAVI funding and hep B, Hib, and DPT vaccination levels and suggests that countries just
above the income cutoff, which receive no Gavi funding, are rolling out DPT and hep B as well as or better than countries just below the threshold, which
do receive Gavi funding. In that sense, the vaccine aid near the threshold was “fungible”—Gavi purchased and distributed vaccines which would have been
funded by countries even in the absence of its support. (Note the evidence suggests wastage is a fairly minor issue—the considerable majority of vaccines
delivered by Gavi are used to immunize children.)

The story is notably different with more expensive vaccines. Delivery of a Gavi-funded rotavirus vaccine actually increases coverage by more than doses
delivered, while delivery of Hib vaccines sufficient to immunize 100 percent of infants would lead to an increase in vaccination coverage of just 72
percent.

It is important to emphasize that the fungibility results for cheap vaccines are applicable only to countries near the eligibility threshold. There are
good reasons to suspect free vaccines had a bigger impact on immunization rates in poorer countries with weaker vaccination programs in the absence of aid.
However, some fungibility occurred even at lower income levels. In 2000, DPT coverage in eligible countries was 70 percent. For those countries which
received enough pentavalent vaccines (which includes DPT) from Gavi to cover 100 percent of children, if they had not reduced their own DPT purchases from
2000 levels to zero, they would have had an average of 70 percent more doses than children to vaccinate. In other words, the choice to dedicate most Gavi
funding over the past decade to the combined pentavalent vaccine essentially crowded out countries’ own spending on some of its less expensive component
vaccines such as DPT.

Figure 2: Gavi’s Impact at the Eligibility Threshold

Gavi's impact at the elegibility threshold

Vaccine Cost as a Barrier to Rollout

One interpretation for these results is that prices for cheap vaccines are not the major barrier to rollout at the cutoff. Studies from the late 1990s in
Bangladesh, Côte d’Ivoire, and Morocco suggested total costs of $21 to $24 per fully immunized child per year.

[5]

Traditional vaccines account for an average of 8–29 percent of total costs compared to labor accounting for 30–46 percent of total costs.

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Conversely, in cases where a more expensive vaccine is added to the schedule to reach those already covered by vaccination services, the vaccine cost will
be the predominate source of cost growth.

There are also increasing marginal costs in reaching children through the vaccine supply network. Mobile vaccination strategies that bring vaccines closer
to children cost $26 per fully immunized child compared to facilities-based approaches (that bring children to permanent clinics) of $14—but countries are
unlikely to get to 90 percent coverage or more without using mobile strategies.

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And covering the “last mile” will take a focus not just on extending access to vaccines, but making sure parents bring their children to get immunized.
Using incentive rewards and improved access to vaccination camps increased vaccine coverage in Rajasthan, India, for example, but at a combined cost of
about $28 per fully immunized child.

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Newer forthcoming studies on vaccine delivery costs suggest even higher per-child costs.

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This implies that in some cases, the $20 in performance-based financing provided by Gavi for increased immunization coverage may have been well below the
marginal cost of extending that coverage. And the cost of vaccines themselves is likely to be the major barrier to rollout only in the case of
comparatively expensive vaccines.

Policy Implications

It is perhaps unsurprising that a single threshold for support may not lead to the most cost-effective spending across the board. This suggests the
considerable value in ongoing discussions within Gavi about modifying policies regarding the threshold and the selection of candidate vaccines for subsidy.
The Alliance might consider the options presented below in Table 1 (which also shows current financing levels):

  1. Our results show no impact of Gavi support on cheap vaccines in middle-income countries near the eligibility cutoff
    , which suggests that a greater focus on the poorest countries will have a larger impact. Gavi should consider lowering the GNI threshold in the case of
    vaccines that are now low-priced (which now includes the pentavalent vaccine). The Alliance might also assess current vaccine purchasing in recipient
    countries, taking care not to substitute for existing expenditure or to assure that a new vaccine is truly more cost-effective—in terms of greater coverage
    or greater efficacy—than existing alternatives. Gavi might introduce a higher income threshold for the option for countries to participate in pooled
    purchasing arrangements to assure that affordability is maintained over time.


  2. It is less clear that middle-income countries will purchase expensive, new vaccines such as rotavirus and pneumococcal without Gavi support.

    This suggests that Gavi should maintain or (potentially) raise the GNI threshold or continue its current policy of extending graduation periods for
    cost-effective vaccines that remain expensive. This could be done on a case-by-case basis linked to the price of the vaccine, alongside pushing for lower
    prices and maintaining and perhaps deepening phased cofinancing requirements considerably below the current threshold.


  3. While most children in developing countries are already vaccinated with older, cheaper vaccines, there are huge potential health benefits from reaching
    the last 10–15 percent of children since these vaccines address illnesses with high mortality rates.

    That may require greater focus on expanding the vaccination delivery system, not just providing more doses.

Table 1: What Should Gavi Do?

Low-income countries

Lower-middle-income countries

Funding per infant

Re­com­menda­tion

Funding per infant

Re­com­menda­tion

1. Cheap vaccines

$4.83

$4.02

2. Expensive vaccines

$3.20

$7.00

3. Delivery network

$1.82

$1.78

4. New vaccines

Dollar figures show Gavi’s annual funding per infant per year (2000–13 for row 1 and row 3; 2008–13 for row 2). Arrows indicate our broad recommendation, relative to current budget shares: raise ↑;
lower ↓.




[1]

WHO and UNICEF, “Global Immunization Data” (February 2014),

www.who.int/immu­nization/monitoring_­surveillance/Global_­Immuni­zation_Data.pdf

.


[2]

Authors’ calculations using disbursement data from Gavi, available at www.gavi.org/results/disbursements/.


[3]

Authors’ calculations using UNICEF’s data on Gavi shipments in 2014 and World Bank population estimates in 2013, the most recent year of data
available in the World Bank’s Databank. Both Gavi-financed and cofinanced shipments were included.


[4]

The ineligible sample is made up of the 73 developing countries in order of increasing income from above the GNI cutoff.


[5]

P. Khaleghian, “Immunization Financing and Sustainability: A Review of the Literature,” Special Initiatives Report No. 40 (Bethesda: Partnerships
for Health Reform Project, Abt Associates, Inc, 2001).


[6]

L. Brenzel et al., “Vaccine-Preventable Diseases,” in Disease Control Priorities in Developing Countries 2, Dean T. Jamison et al., eds.
(Washington: The World Bank and Oxford University Press, 2006), 389–412.


[7]

L. Brenzel et al., “Vaccine-Preventable Diseases.”


[8]

A. Banerjee, E. Duflo, R. Glennerster, and D. Kothari, “Improving Immunisation Coverage in Rural India: Clustered Randomised Controlled Evaluation
of Immunisation Campaigns with and without Incentives,” BMJ 2010;340:c2220.


[9]

G. Gotsadze, K. Goguadze, I. Chikovani, and D. Maceira, “Analyses of Costs and Financing of the Routine Immunization Program and New Vaccine
Introduction in the Republic of Moldova,” Curatio International Foundation, 2013.